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style="color: rgb(0, 92, 172); text-decoration: none;">中國科學院</a><a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">上海</a><a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">生命科學研究院</a>生物化學與<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">細胞生物學</a>研究所王綱研究組的研究成果Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling。該論文報道了轉錄中介體Med23基因在胚胎干細胞向神經細胞分化過程中的重要作用。</p><p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">王綱研究組的朱萬渠、姚瀟、梁燕同學系統地對Med23敲除<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">胚胎干細胞</a>進行干性及細胞分化的多種特征鑒定，通過多種研究手段發現Med23缺失不會改變胚胎干細胞的全能性及自我更新，但是會促進其向神經細胞方向分化。同時RNA干擾敲低其他亞基，例如Med1和Med15，并不會影響胚胎干細胞向神經分化。進一步分子機制研究發現，Med23通過調節BMP信號通路來影響胚胎干細胞向神經分化;具體地， Med23通過轉錄因子ETS1來控制Bmp4基因的啟動子及增強子的功能，從而調控Bmp4的表達。在<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">模式生物斑馬魚</a>研究中發現，敲低Med23的表達水平也能促進早期神經發育。這項工作揭示了轉錄中介體Med23亞基在神經分化過程中的重要功能，闡明了胚胎干細胞分化過程中的一種內在的調控機制，為神經退行性疾病的細胞治療提供了一種可能的方法和思路。</p><p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">該工作得到了中科院、科技部以及國家<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">自然科學基金</a>的經費支持，研究過程中還獲得了生化與細胞所研究員景乃禾、李勁松的大力支持與幫助。</p><p><br/></p> </div> <div class="pager ks-clear"> <span class="iconfont1 iconjiantou newsjiantou-left" style="font-size: 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