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class="content-box n-box"> <div class="body-right"> <div class="breadCrumb ThemeFborder"> <b>您當前的位置：</b><a href="/">首頁</a><em>></em> <a href="/Article-index.html" class="Themefont">下載</a><em>></em><a href="/Articles-24510.html" class="Themefont">行業資訊</a> </div>   <div class="row"> <div class="news-nr-box"> <style> body .news-nr-box h1{ font-size:18px; font-family:Airal; text-align:center; line-height:25px; padding: 10px 0; margin:0px; color:#333; } </style> <div class="news1-title"> <h1>PNAS：基因組穩定性的關鍵</h1> <h6> <span>2015-12-10</span> <span>　來自:  湛江市?？粕锟萍加邢薰? </span> <span style="margin-left:10px;">瀏覽次數:1123</span> </h6> </div> <p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">2011年四月，著名學術期刊《<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">Cell</a>》刊登一份撤稿聲明稱，應美國辛辛那提大學副教授杜春英(Chunying Du)課題組要求，撤銷他們于2009年發表在《Cell》上涉及酶caspase-2功能意義的一篇論文。</p><p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">時隔四年，該課題組于三月二日在《<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">PNAS</a>》發表一項重要研究成果，在這項研究中他們發現了一個新的蛋白，可幫助保持基因組的穩定性，這一有發現非常有前景，有可能幫助研究人員為遺傳不穩定性疾病(如癌癥)開發新的靶向治療方法。</p><p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">本文通訊作者、辛辛那提癌癥中心成員杜春英博士說：“DNA損傷修復對于基因穩定性的保持至關重要。未修復的DNA，尤其是DNA雙鏈斷裂，對細胞的毒性很強。如果未修復，DNA雙鏈斷裂往往會導致基因突變，這會促進惡性<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">腫瘤細胞</a>的生長和腫瘤的發展。</p><p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">“在這項研究中，我們發現了一種凋亡抑制劑蛋白(叫做BRUCE)的一個以前未知的功能——凋亡抑制劑阻礙<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">細胞死亡</a>，以及一種去泛素化酶(稱為USP8)，其控制著我們身體的許多其他代謝功能。它們共同促進DNA損傷修復和預防遺傳不穩定性。BRUCE和USP8通過允許一個著名的腫瘤抑制基因BRIT1到達DNA損傷部位，而發揮其功能?！?/p><p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">本文作者Chunmin Ge指出：“我們還定義了一個分子通路，在該通路中BRUCE和USP8激活BRIT1來化細胞對<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">DNA</a>損傷的響應能力。BRUCE使這三個蛋白團結在一起，讓USP8除去BRIT1上的泛素蛋白鏈，將BRIT1釋放到DNA損傷位點以修復DNA斷裂?！?/p><p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">這項研究的合作者包括：本文第二作者、杜春英<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">實驗室</a>博士后Lixiao Che博士以及來自蘭州第二人民醫院的研究人員;休斯敦衛理公會研究所、貝勒醫學院、華盛頓大學的研究人員。</p><p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">癌癥<a target="_blank" style="color: rgb(0, 92, 172); text-decoration: none;">生物學</a>系教授Jun-Lin Guan博士表示：“這項工作非常重要。它揭示了對癌癥調控非常關鍵的兩個重要細胞過程之間的聯系，并發現了相關的分子機制。這是該實驗室多年來對基本癌癥機制認真細致研究的積累。這種新型的、創造性的基礎研究，對于推動未來癌癥新療法的發展至關重要?！?/p><p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">杜博士說，這項研究對“去除泛素鏈對于DNA修復調控是多么重要”提出了重要見解，并且她的團隊現在將致力于確定BRUCE-USP8-BRIT1通路中的突變，這些突變可能與DNA修復缺陷和基因組不穩定性造成的疾病發展有關。</p><p style="margin-top: 10px; margin-bottom: 10px; font-size: 14px; text-indent: 2em; line-height: 25px; overflow: hidden; width: 839.984375px; white-space: normal; background-color: rgb(255, 255, 255); padding: 0px; color: rgb(51, 51, 51); font-family: helvetica, tahoma, arial, 宋體, sans-serif;">杜博士表示：“我們很高興看到這項合作性成果得以發表。我們的研究結果，為DNA損傷反應網絡這個相當復雜的難題，提供了重要的信息?！?/p><p><br/></p> </div> <div class="pager ks-clear"> <span class="iconfont1 iconjiantou newsjiantou-left" style="font-size: 32px!important;display: none;" ></span> <div class="previous fl"> <span style="padding-top: 5px;">上一條：</span> <a title="大口咀嚼蔬菜時，你有在意過蔬菜的感受么？" class="Themebg Themebghover" href="/Article-detail-id-369884.html">大口咀嚼蔬菜時，你有在意...</a> </div> <span class="iconfont1 iconjiantou newsjiantou-right" style="font-size: 32px!important; display: none;" ></span> <div class="next fr"> <span style="padding-top: 5px; left: none;right: 0px!important;">下一條：</span> <a title="能源救星-微生物能源" class="Themebg Themebghover" href="/Article-detail-id-369886.html">能源救星-微生物能源</a> </div> <div class="clear"></div> </div>  <div class="pro_keyword"> 關鍵詞： <a class="Themetxthover Themefont" href="/Article-searchAll-name-%E6%B0%B4%E4%BA%A7%E7%94%9F%E7%89%A9%E8%82%A5.html">水產生物肥</a> <a class="Themetxthover Themefont" 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